The 1st China-Japan-Korea International Meeting (July 28-31, 2021)

held jointly with the 44th Annual Meeting of the Japan Neuroscience Society in Kobe, Japan
All programs will be held virtually via Zoom (Lectures) or on Virbela Platform (Posters)

Program

Plenary Lectures

Prof Richard W. Tsien: July 29 (Thu) 8-9AM
(Druckenmiller Professor of Neuroscience & Chair, Department of Neuroscience and Physiology
Director, Neuroscience Institute, New York University Grossman School of Medicine)

Prof Yulong Li: July 31 (Sat) 8-9AM
(Professor of Life Sciences, IDG/ McGovern Institute for Brain Research, Peking University)

Prof Hee-Sup Shin: July 31 (Sat) 12-1PM
(Professor, Center for Cognition and Sociality, Institute for Basic Science, Daejeon, Korea)

Symposium

Wed July 28
9:00-11:00 Symposium 1: Amyotrophic Lateral Sclerosis
Symposium 2: Molecular and Cellular Neuropsychiatry
16:40-18:40 Symposium 3: Reactive astrocytes as the causes of neurodegenerative diseases
Symposium 4: Sensory/motor information processing in the brain of non-human primates
Thu July 29
9:00-11:00 Symposium 5: New technologies for visualizing and controlling the brain functions
Symposium 6: Stem cell derived neurons for studying human neurological disorders
16:40-18:40 Symposium 7: Dynamic Memory: molecular, cellular and systems approaches
Symposium 8: Novel brain functions revealed by precise measurement and manipulation of monoamine signals
Fri July 30
9:00-11:00 Symposium 9: Interplay of multiple types of plasticity in the cerebellar network
Symposium 10: Mechanisms of Innate Fear
16:40-18:40 Symposium 11: Neural circuits of social-emotional behaviors
Symposium 12: Stem Cell Neurobiology
Sat July 31
9:00-11:00 Symposium 13: Imaging Human Cognition
Symposium 14: Hypothalamic control of behaviors and homeostasis
Symposium 15: Neural mechanisms of fear memory
Symposium 16: Understanding and modeling cerebellar functions
14:00-16:00 Symposium 17: Bridging the gap between experiments and theories
Symposium 18: Cortical Development and Organization
Symposium 19: Neural organoids for studying human development and diseases
Symposium 20: Glial mechanisms of circuit regulation

Posters

A total of 502 abstracts (CJK and JNS combined) will be presented at the Virbela Virtual Expo Hall on July 31st.

Symposium 1: Amyotrophic Lateral Sclerosis (Wednesday July 28, 9-11AM JST)

Chair: Seung Hyun Kim (Hanyang University Hosp, Seoul, Korea )

9:00-9:40 Seung Hyun Kim (Hanyang University Hosp, Seoul, Korea)
WES based identification of novel pathogenic mutations and their roles in neuronal cell death mechanisms in ALS and FTD-ALS spectral diseases
9:40-10:20 Shinsuke Ishigaki/Gen Sobue (Nagoya Univ Sch of Med, Nagoya, Japan)
Aberrant FUS-SFPQ interactions in the neuronal nuclei in ALS and FTLD spectrum diseases, a possible pathogenesis
10:20-11:00 Shuo-Chien Ling (Natl Univ Singapore, Singapore)
TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination

Symposium 2: Molecular and Cellular Neuropsychiatry (Wed July 28, 9-11AM JST)

Chair: Akira Sawa (Johns Hopkins Univ, Baltimore, USA)

9:00-9:30 Jeong-Ho Lee (KAIST, Daejeon, Korea)
Brain somatic mutations disrupting neural circuits
9:30-10:00 Atsushi Takata (RIKEN-CBS, Wako-Saitama, Japan)
The rare variant genetics of neuropsychiatric disorders; exome sequencing and beyond
10:00-10:30 Jacque Pak Kan Ip (The Chinese Univ of Hong Kong, China)
Investigating the roles of circular RNAs in synaptic plasticity
10:30-11:00 Minae Niwa (The Univ of Alabama at Birmingham, USA)
Adolescent social isolation-induced vulnerability to postpartum mental disturbance via prolonged dysregulation of the HPA axis

Symposium 3: Reactive astrocytes as the causes of neurodegenerative diseases (Wed July 28, 16:40-18:40 JST)

Chair: C. Justin Lee (Institute for Basic Science, Daejeon, Korea)

16:40-17:10 Alexej Verkratsky (Univ of Manchester, UK)
Astrocyte iron homeostasis: links to astrogliosis and neurodegeneration
17:10-17:40 Jia-wei Zhou (Inst. of Neurosci. Chinese Academy of Sciences, China)
EBF1/RGS5 axis modulates astrocyte activation and facilitates neurodegeneration
17:40-18:10 Schuichi Koizumi (Interdisc. Grad Sch Med, Univ of Yamanashi, Japan)
Reactive astrocytes control brain pathogenesis via uncontrolled synaptogenesis
18:10-18:40 C. Justin Lee (Cntr for Cognition and Sociality, IBS, Korea)
Astrocytic urea cycle impairs memory in Alzheimer's disease.

Symposium 4: Sensory/motor information processing in the brain of non-human primates (Wed July 28, 16:40-18:40 JST)

Chairs: Dajun Xing (Beijing Normal Univ, China) and Yong Gu (Inst. of Neurosci., Shanghai, China)

16:40-17:10 Dajun Xing (Beijing Normal Univ. China)
Laminar subnetworks of response suppression in macaque primary visual cortex
17:10-17:40 Joonyeol Lee (Sungkyunkwan Univ Cntr for Neurosci Imaging Res, Korea)
Effect of prior expectation on the neural responses in area MT during a sensory-motor behavior
17:40-18:10 Yong Gu (Inst of Neurosci, Chinese Academy of Sciences, China)
Synchrony of visual and nonvisual cues for multisensory heading perception
18:10-18:40 Hironori Kumano (Dept of Integr Physiol, Grad Sch Med, Univ of Yamanashi, Japan)
Neural mechanism of flexible visual decision making

Symposium 5: New technologies for visualizing and controlling the brain functions (Thu July 29, 9-11AM JST)

Chair: Won Do Heo (KAIST, Daejeon, Korea)

9:00-9:30 Won Do Heo (KAIST, Daejeon, Korea)
Molecular optogenetics: tool development and applications from cell biology to neuroscience
9:30-10:00 Robert E. Campbell (Dept of Chem, Sch of Sci, Univ of Tokyo, Japan and Univ of Alberta, Canada)
Recent progress in developing genetically encoded ion sensors
10:00-10:30 Michael Z. Lin (Stanford Univ Sch of Med, California, USA)
The need for speed: kilohertz-rate voltage imaging in the nervous system
10:30-11:00 Young-Gyun Park (Dept of Bio and Brain Eng, KAIST, Korea)
Demystifying brain network using 3D tissue profiling techniques

Symposium 6: Stem cell derived neurons for studying human neurological disorders (Thu July 29, 9-11AM JST)

Chairs: Jun Yao (Tsinghua University, China) and Jinju Han (KAIST, Korea)

9:00-9:30 Jinju Han (Grad Sch Med Sci & Eng, KAIST, Korea)
microRNAs in neuronal development and diseases
9:30-10:00 Yan Liu (Nanjing Medical University, China)
Suppressing the DSCAM/PAK1 pathway reverses neurogenesis deficits in Down Syndrome patient iPSC-derived cerebral organoids
10:00-10:30 Tomoyo Sawada (Lieber Inst. for Brain Development, Baltimore, USA)
Dissecting molecular bases of schizophrenia with iPSC-derived brain organoids and postmortem brain tissues
10:30-11:00 Jun Yao (Tsinghua University, Beijing, China)
Investigating the pathogenesis of bipolar disorder using combined iPSC and mouse models

Symposium 7: Dynamic Memory: molecular, cellular and systems approaches (Thu July 29, 16:40-18:40 JST)

Chair: Bong-Kiun Kaang (Seoul National Univ, Korea)

16:40-17:04 Yi Zhong (Tsinghua University, China)
Emotion-mediated switching between latent and silent memory engram
17:04-17:28 Daisuke Miyamoto (University of Toyama, Japan)
In vivo imaging of cortical synaptic dynamics by learning and sleep.
17:28-17:52 Jin-Hee Han (Dept Biological Sciences, KAIST, Korea)
A synaptic activity-dependent competition rule underlying memory formation
17:52-18:16 Johannes Gräff (Ecole Polytechnique Fédérale de Lausanne, Switzerland)
Recent insights into remote fear memory attenuation
18:16-18:40 Denise Cai (Icahn School of Medicine at Mount Sinai, USA)
The brain in motion- how ensemble fluidity supports memory updating.

Symposium 8: Novel brain functions revealed by precise measurement and manipulation of monoamine signals (Thu July 29, 16:40-18:40 JST)

Chair: Sho Yagishita (The University of Tokyo, Japan)

16:40-17:10 Yuki Sugiura (School of Medicine, Keio University , Japan)
In situ imaging of monoamine localization and dynamics by mass spectrometry
17:10-17:40 Rui Lin (National Institute of Biological Sciences, Beijing, China)
The raphe dopamine system controls the expression of incentive memory
17:40-18:10 Sho Yagishita (Graduate School of Medicine, The Univ of Tokyo, Japan)
Disinhibitory gating of discrimination learning and spine enlargement by dopamine D2 receptors in the nucleus accumbens
18:10-18:40 HyungGoo Kim (Department of Biomedical Engineering, Sungkyunkwan University, Korea)
Dopamine signals during spatial navigation

Symposium 9: Interplay of multiple types of plasticity in the cerebellar network (Fri July 30, 9-11AM JST)

Chair: Sang Jeong Kim (Seoul National University College of Medicine, Korea)

9:00-9:30 Sang Jeong Kim (Seoul National University College of Medicine, Korea)
Synaptic and intrinsic plasticity coordinate the spike output in cerebellar Purkinje cells
9:30-10:00 Gen Ohtsuki (Dept Drug Discov Med, Kyoto Univ Grad Sch Med, Japan)
Intrinsic plasticity of the Purkinje-cell dendrites and immune stress
10:00-10:30 Keiko Tanaka-Yamamoto (Korea Institute of Science and Technology)
Chronic stress-induced activity alteration in VTA-projecting cerebellar neurons mediates depressive symptoms
10:30-11:00 Ying Shen (Zhejiang University, China)
MeCP2 deficiency in cerebellar Purkinje cells causes Rett syndrome phenotypes

Symposium 10: Mechanisms of Innate Fear (Fri July 30, 9-11AM JST)

Chair: Reiko Kobayakawa (Kansai Medical Univ, Hirakata-Osaka, Japan)

9:00-9:30 Jeansok J Kim (Department of Psychology and Program in Neuroscience, University of Washington at Seattle, USA)
Neurobiology of Stayin' Alive
9:30-10:00 Qinghua Liu (National Institute of Biological Sciences, Beijing, China)
Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice
10:00-10:30 June-Seek Choi (Dept of Psychology, Korea University, Seoul, Korea)
Chasing as a psychogenic stress: implications for aging and sex differences in fear response
10:30-11:00 Ko Kobayakawa (Kansai Medical Univ, Hirakata-Osaka, Japan)
Artificial hibernation/life-protective state induced by thiazoline-related innate fear odors via sensory TRPA1 activation

Symposium 11: Neural circuits of social-emotional behaviors (Fri July 30, 16:40-18:40 JST)

Chair: Hailan Hu (Zhejiang University, Hangzhou, China)

16:40-17:10 Zhihua Gao (Zhejiang Univ Sch of Brain Science and Brain Medicine, China)
The Magnocellular Neuroendocrine System-structural and functional insights
17:10-17:40 Fusao Kato (Jikei University School of Medicine, Tokyo, Japan)
The central amygdala plasticity controls widespread chronic pain
17:40-18:10 Kun Li (Tsinghua University, Beijing, China)
A Cortico-hypothalamic circuit controls estrus-dependent sociosexual behavior in females
18:10-18:40 Ja Wook Koo (Korea Brain Research Institute, Daegu, Korea)
Dopaminergic regulation of accumbal cholinergic interneurons defining susceptibility to cocaine addiction

Symposium 12: Stem Cell Neurobiology (Fri July 30, 16:40-18:40 JST)

Chair: Mototsugu Eiraku (Kyoto University, Kyoto, Japan)

16:40-17:04 Haruhisa Inoue (CIRA, Kyoto University, Japan)
AI drug discovery and diagnosis support with ALS patient iPSC panel
17:04-17:28 Asuka Morizane (Kobe City Med Cntr General Hospital, Kobe, Japan)
Cell therapy for Parkinson's disease with induced pluripotent stem cells
17:28-17:52 Mototsugu Eiraku (Kyoto University, Kyoto, Japan)
Self-organized formation of functional tissues from pluripotent stem cells
17:52-18:16 Michiko Mandai (RIKEN-BDR, Kobe, Japan)
Regenerative therapy using ESC/iPSC-derived retinas for retinal degeneration
18:16-18:40 Guo-li Ming (University of Pennsylvania)
Engineering Organoid Models for Understanding Human Neurodevelopment and Neurological Diseases

Symposium 13: Imaging Human Cognition (Sat July 31, 9-11AM JST)

Chair: Fang Fang (School of Psychological and Cognitive Sciences, Peking University)

9:00-9:30 Yuji Naya (School of Psychol & Cognitive Sciences, Peking University, China)
Objects and space in the medial temporal lobe memory system
9:30-10:00 Masahiko Haruno (NICT Center for Information and Neural Networks, Osaka, Japan)
Functional connectivity basis and underlying cognitive mechanisms for gender differences in guilt aversion
10:00-10:30 Won Mok Shim (School of Biomedical Engineering, Sungkyunkwan University, Korea)
Dynamics of brain states in naturalistic cognition
10:30-11:00 Fang Fang (School of Psychological and Cognitive Sciences, IDG/McGovern Institute for Brain Research, Peking University, China)
Maps and functions of human attention

Symposium 14: Hypothalamic control of behaviors and homeostasis (Sat July 31, 9-11AM JST)

Chair: Xiao-Hong Xu (Institute of Neuroscience, Chinese Academy of Sciences. Shanghai, China)

9:00-9:24 Clifford B. Saper (Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, USA
Preoptic control of sleep and body temperature
9:24-9:48 Wei Shen (Shanghaitech University, Shanghai, China)
The Brainstem-Hypothalamic circuitry controls body temperature
9:48-10:12 Sakiko Honjoh (University of Tsukuba, International Institute for Integrative Sleep Medicine, Japan)
Thalamic regulation of sleep and wakefulness
10:12-10:36 Jong-Woo Sohn (Korea Advanced Institute of Science and Technology, Daejeon, Korea)
Hypothalamic mechanisms for serotonergic regulation of feeding
10:36-11:00 Qing-Feng Wu (Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China)
Tbx3 dictates arcuate Tac2 neurons to control timing of puberty onset

Symposium 15: Neural mechanisms of fear memory (Sat July 31, 9-11AM JST)

Chairs: Kenta Hagihara (Friedrich Miescher Inst., Basel) and Takaaki Ozawa (Osaka Univ)

9:00-9:30 Kenta Hagihara (Friedrich Miescher Inst., Basel, Switzerland)
Mutual inhibition between intercalated amygdala clusters orchestrates a switch in fear state
9:30-10:00 Sung Han (Salk Institute, San Diego, USA)
Encoding multi-sensory threat signals to the amygdala by peptidergic circuits
10:00-10:30 Li-Feng Yeh (RIKEN-CBS, Wako, Japan)
An aversive-sensorimotor neural circuit for instructing associative fear memories
10:30-11:00 Yingxi Lin (SUNY Upstate Medical University, USA)
Functionally distinct active neuronal ensembles

Symposium 16: Understanding and modeling cerebellar functions (Sat July 31, 9-11AM JST)

Chairs: Shogo Ohmae (Baylor College of Medicine) and Olivia Kim (Princeton)

9:00-9:30 Shogo Ohmae (Baylor College of Medicine, Houston, USA)
The temporal-difference error signals of the climbing fibers and their origins during cerebellar learning in mice
9:30-10:00 Olivia A. Kim (Princeton University, Princeton, USA)
Inhibition of the inferior olive is sufficient for extinction of cerebellar motor learning
10:00-10:30 Yunliang Zang (Brandeis University, Waltham, USA)
Multiplexed coding in cerebellar Purkinje neurons
10:30-11:00 Tadashi Yamazaki (Univ of Electro-Communications, Tokyo)
High-performance simulation of cerebellar neurons and microcircuits

Symposium 17: Bridging the gap between experiments and theories (Sat July 31, 14:00-16:00 JST)

Chair: Se-Bum Paik (Korea Advanced Institute of Science and Technology, Daejeon, Korea)

14:00-14:30 Kenji Doya (Neural Computation Unit, Okinawa Institute of Science and Technology Graduate University, Japan)
The duality of control and inference as a clue for cracking the codes of frontal and sensory cortical architectures
14:30-15:00 Tatyana O. Sharpee (Salk Institute for Biological Studies, USA)
Reading out responses of large neural population with minimal information loss
15:00-15:30 Se-Bum Paik (Korea Advanced Institute of Science and Technology, Daejeon, Korea)
Emergence of cognitive functions in untrained neural networks
15:30-16:00 Li Zhaoping (Univ of Tübingen and Max Planck Inst for Biological Cybernetics, Germany)
From V1SH to CPD, a new framework for understanding vision.

Symposium 18: Cortical Development and Organization (Sat July 31, 14:00-16:00 JST)

Chairs: Song-Hai Shi (Tsinghua University, Beijing) and Fumio Matsuzaki (RIKEN-BDR, Kobe)

U14:00-14:30 Pierre Vanderhaeghen (VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, Brussels, Belgium)
Human-specific temporal mechanisms of brain development
14:30-15:00 Fumio Matsuzaki (RIKEN Center for Biosystems Dynamics Research, Kobe, Japan)
Exploring the relationship of progenitor subtypes in and between gyrencephalic species at the single cell level
15:00-15:30 Xiang Yu (Peking University, Beijing, China)
Regulation of spinogenesis and functional synapse formation by experience and DHA
15:30-16:00 Itaru Imayoshi (Kyoto University, Japan)
Analysis of neural stem cell regulatory mechanisms using optogenetics

Symposium 19: Neural organoids for studying human development and diseases (Sat July 31, 14:00-16:00 JST)

Chairs: Woong Sun (Korea University, Seoul) and Hyunsoo Shawn Je (Duke-NUS, Singapore)

14:00-14:30 Hyunsoo Shawn Je (Duke-National Univ of Singapore Med Sch, Singapore)
Modeling Neural Disorders Using Human Pluripotent Stem Cells
14:30-15:00 Jinsoo Seo (Daegu Gyeongbuk Institute of Science & Technology, Korea)
Modeling Alzheimer's disease with human iPSC-derived cerebral organoids
15:00-15:30 Yoshiho Ikeuchi (Institute of Industrial Science, The Univ of Tokyo, Japan)
An Organoid-on-a-chip Approach for Modeling Macroscopic Neural Circuits in vitro
15:30-16:00 Kinichi Nakashima (Grad Sch Med Sci, Kyushu University, Japan)
MeCP2 controls neural stem cell fate specification through microRNA-mediated inhibition of BMP-Smad signaling

Symposium 20: Glial mechanisms of circuit regulation (Sat July 31, 14:00-16:00 JST)

Chairs: Woo-ping Ge (Chinese Inst for Brain Research, Beijing) and Bo Peng (Fudan Univ, Shanghai)

14:00-14:20 Soyon Hong (UKDRI, University College London, UK)
Microglia as synaptic pruners in Alzheimer's disease
14:20-14:40 Xiaoping Tong (Sch Med, Shanghai Jiao Tong Univ, China)
NG2 glia, GABA synapse and its beyond
14:40-15:00 Feng Mei (Third Military Medical Unversity, Chongqing, China)
Myelin dynamics in Alzheimer's disease
15:00-15:20 Won-Suk Chung (Dept Biol Sci, KAIST, Korea)
Phagocytic roles of glia in eliminating adult synapses
15:20-15:40 Eunji Cheong (Dept Biotech., Div. Life Sci., Yonsei University, Korea)
Astrocytic control of thalamic sensory processing
15:40-16:00 Mami Noda (Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka, Japan)
Involvement of microglia and medical gas therapy for the persistent fatigue after COVID-19